Alpha Synuclein-rPeptide Introduces New proteins
Summary
Alpha Synuclein, 1-60
Alpha Synuclein, 1-95
Alpha Synuclein, 61-140
Alpha Synuclein, 96-140
Alpha Synuclein, 1-60
6,149 Da
Lyophilized powder. Purity > 95% by SDS-PAGE; A deletion mutant of Alpha-Synuclein (amino acids 1-60), which contains the N-terminal amphipathic domain. Alpha-Synuclein is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. Alpha-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. Alpha-Synuclein appears to associate with other proteins that aggregate and is found in amyloid plaques and neuritic tangles in Alzheimer’s disease.
Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
Jakes, R. et al. 1994, FEBS Letters, 345, 27
Masliah, E. et. al., 2001. Proc. Natl. Acad. Sci., USA, 98, 12245
Ueda, K., et. al. 1993. Proc. Natl. Acad. Sci., USA, 90, 11282
For more info:
http://www.rpeptide.com/products/product_details_112.html
Alpha Synuclein, 1-95
9,391 Da
Lyophilized powder. Purity > 95% by SDS-PAGE; A deletion mutant of Alpha-Synuclein (amino acids 1-95), which contains the N-terminal amphipathic domain and the NAC region. Alpha-Synuclein is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. Alpha-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. Alpha-Synuclein appears to associate with other proteins that aggregate and is found in amyloid plaques and neuritic tangles in Alzheimer’s disease.
Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
Jakes, R. et al. 1994, FEBS Letters, 345, 27
Masliah, E. et. al., 2001. Proc. Natl. Acad. Sci., USA, 98, 12245
Ueda, K., et. al. 1993. Proc. Natl. Acad. Sci., USA, 90, 11282
For more info:
http://rpeptide.com/products/product_details_113.html
8,460 Da
Lyophilized powder. Purity > 95% by SDS-PAGE; A deletion mutant of Alpha-synuclein (amino acids 61-140). Additional amino acid (Met) is attached at the N-terminus. Alpha-Synuclein is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. Alpha-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. Alpha-Synuclein appears to associate with other proteins that aggregate and is found in amyloid plaques and neuritic tangles in Alzheimer’s disease.
Park, S. M. et al. (2002) Blood, 100(7) 2506
Park, S. M. et al. (2002) Biochemisty. 41, 4137
Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
Jakes, R. et al. 1994, FEBS Letters, 345, 27
Masliah, E. et. al., 2001. Proc. Natl. Acad. Sci., USA, 98, 12245
Ueda, K., et. al. 1993. Proc. Natl. Acad. Sci., USA, 90, 11282
For more info:
http://rpeptide.com/products/product_details_114.html
5,217 Da
Lyophilized powder. Purity > 95% by SDS-PAGE; A deletion mutant of Alpha-Synuclein (amino acids 96-140). Additional amino acid (Met) is attached at the N-terminus. Alpha-Synuclein is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. Alpha-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. Alpha-Synuclein appears to associate with other proteins that aggregate and is found in amyloid plaques and neuritic tangles in Alzheimer’s disease.
Park, S. M. et al. (2002) Blood, 100(7) 2506
Park, S. M. et al. (2002) Biochemisty. 41, 4137
Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
Jakes, R. et al. 1994, FEBS Letters, 345, 27
Masliah, E. et. al., 2001. Proc. Natl. Acad. Sci., USA, 98, 12245
Ueda, K., et. al. 1993. Proc. Natl. Acad. Sci., USA, 90, 11282
For more info:
http://rpeptide.com/products/product_details_115.html
Company Info:
rPeptide is a biotechnology company located in Athens, Georgia, USA, and is a market leader in providing research products (recombinant peptides and proteins, antibodies, reagents) for Alzheimer’s disease and Parkinson’s disease research. rPeptide also provides a range of custom services from molecular biology, protein expression and purification, to 13C and 15N uniform labeling of peptides and proteins.
rPeptide has a proprietary platform vector technology that enables the expression of historically difficult peptides/proteins as soluble peptides/proteins (like amylin, beta-amyloid, leptin, pro-insulin) in E. coli. For more information, contact:
Sanjay Bhardwaj
4241 Mars Hill Road,
Bogart, GA 30622, USA
Tel: 678-753-0747
Fax: 678-753-0746
sanjayb@rpeptide.com
www.rpeptide.com
